Join our Volunteer Research Register
Volunteers wanted for research into a new depression treatment

Volunteers wanted for research into depression, bipolar disorder, anxiety, and stress

The main physical treatments for depression comprise:

New treatments being trialled at the Black Dog Institute include:

Drug Treatments

There are three groups of drugs most likely to be used for depression:

Antidepressants

  • There is a large number of antidepressants - they have a role in many types of depression and vary in their effectiveness across the more biological depressive conditions.
  • Selective Serotonin Reuptake Inhibitors (SSRIs), Tricyclics (TCAs) and Irreversible Monoamine Oxidase Inhibitors (MAOIs) are three common classes of antidepressants. They each work in different ways and have different applications.
  • At the Institute we believe that they are not, however, equally effective and that it is necessary to find the right antidepressant for each person.
  • If the first antidepressant does not work, it is sensible to move to a different kind of antidepressant. For the biological depressive disorders, more broad action antidepressants are usually more effective.
  • A well-informed health provider should be able to use their assessment of the type of depression, its likely causes and their understanding of the person to identify the medication most likely to benefit.
  • Finally, being able to decide not to use medication is important too.

Tranquillisers

  • These medications are usually called 'minor' or 'major' tranquillisers.
  • Minor tranquillisers (typically benzodiazepines) are not helpful in depression; they are addictive and can make the depression worse.
  • Major tranquillisers are very useful in people with a psychotic depression and in melancholia where the person is not being helped by other medications.

'Anti-manic' drugs or 'mood stabilisers'

  • These drugs are of great importance in bipolar disorder.
  • Their use in treating mania makes them 'anti-manic', while their ability to reduce the severity and frequency of mood swings makes them 'mood stabilisers'.
  • Lithium, valproate and carbamazepine are the most common, while use of lamotrigine is increasing.

It is important to remember that the anti-depressants and mood stabilisers are often necessary both to treat the depression that is occurring now, and to make a relapse in the future less likely. So people sometimes need to continue taking medication for some time after they are better.

Electroconvulsive Therapy (ECT)

Because of its controversial past many people feel the need to think carefully before having ECT or allowing it to be given to relatives.

Clinicians at the Institute firmly believe that ECT has a small but important role in treatment, particularly in cases of

  • Psychotic depression
  • Severe melancholia where there is a high risk of suicide or the patient is too ill to eat, drink or take medications
  • Life-threatening mania
  • Severe post-natal depression.

While there are some short-term side-effects, ECT is relatively safe and, because an anaesthetic is used, not too unpleasant.

Further information on ECT

Direct current stimulation (DCS) also known as Mild brain stimulation (MBS)

Researchers at the Institute are now investigating a promising new treatment for depression called direct current stimulation (DCS). Studies around the world, including a recently completed study at the Institute, have found that DCS has significant antidepressant effects and is a potential alternative to medication and electroconvulsive therapy (ECT). In DCS, very weak currents are used to stimulate relevant parts of the brain via two rubber electrodes placed on the head. The stimulation is painless with no known serious side effects. Unlike ECT, there is no need for a general anaesthetic nor is a convulsion induced. The patient is fully awake and alert during the 30 minute treatment sessions.

Watch a presentation about DCS

Find out more...

How Direct current stimulation (DCS) compares with Transcranial magnetic stimulation (TMS)

Another physical treatment for depression is transcranial magnetic stimulation (TMS). This is a procedure used diagnostically by neurologists to test brain functioning, and has recently been studied by psychiatrists as a treatment for depression. In TMS, a coil is held next to the patient's head and a magnetic field is created to stimulate relevant parts of the brain. It has been found to be very safe, with few side effects.

In comparison, DCS:

  • Is not painful
  • Has no seizure risk
  • Appears to be as effective from trials so far

See our Depression Education Program for more information about treating depression.